Seahawks vs Cardinals Predictions: Can Seattle Upset Arizona in a Divisional Clash?
The NFC West rivalry heats up as the Seattle Seahawks face the Arizona Cardinals in a matchup that carries both playoff implications and betting intrigue. With both teams sitting at 2-1, this primetime clash promises defensive intensity, star performances, and questions about which offense can rise to the occasion.

Seahawks vs Cardinals: Odds and Betting Lines
Sportsbooks are projecting a razor-thin contest between the Seahawks and Cardinals. Arizona opens slightly favored, but Seattle’s recent performances have bettors split on the outcome.
Market | Line / Odds | Notes |
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Spread | Seahawks +1.5 | Seattle expected to keep it close |
Moneyline | Seahawks +100 / Cardinals -120 | Arizona favored slightly at home |
Over/Under | 43.5 points | Many analysts leaning on the under |
The narrow lines suggest that bookmakers view this as a defensive battle rather than a high-scoring shootout.
Injury Report and Player Availability
Injuries are shaping the outlook for this game in a big way.
Arizona Cardinals:
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James Conner is likely out for the season with an ankle injury.
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Without their star running back, the Cardinals’ rushing attack becomes far less threatening.
Seattle Seahawks:
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Robbie Ouzts and Josh Jones are dealing with ankle injuries.
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Key contributors like Devon Witherspoon, Julian Love, Nick Emmanwori, and Zach Charbonnet remain under evaluation for availability.
The loss of Conner tilts the balance in favor of Seattle’s defensive front, which thrives when opponents are one-dimensional.
Key Matchups to Watch
Seattle’s Defensive Pressure vs Kyler Murray
The Seahawks’ defensive line has generated consistent pressure through three weeks. If they can contain Kyler Murray in the pocket, Arizona’s passing game may struggle without balance.
Sam Darnold vs Arizona Secondary
Seattle quarterback Sam Darnold has looked increasingly efficient. Against Arizona’s secondary, he will need to stay turnover-free and capitalize on short-yardage gains.
Special Teams Impact
Seattle has benefited from timely special teams plays. In a game projected to be decided by a few points, a blocked kick or return could prove decisive.
Seahawks vs Cardinals Predictions
Experts are divided, but most Seahawks vs Cardinals Predictions point toward a low-scoring game with Seattle either winning outright or covering the spread.
Bold predictions include:
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The Seahawks win on a late field goal.
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Sam Darnold posts one of his most efficient games as a starter.
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Kyler Murray struggles under pressure, throwing at least one interception.
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The total score falls below 43.5 points, consistent with defensive dominance.
Expected Game Flow
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First Half: Arizona tries to establish tempo through Murray’s mobility, but Seattle’s defense limits explosive plays.
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Second Half: With Conner absent, the Cardinals lean heavily on the passing game, giving Seattle’s defense more chances to create turnovers.
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Final Moments: A narrow margin keeps fans on edge, but Seattle’s composure in late-game scenarios may give them the upper hand.
Final Score Prediction
Team | Predicted Score |
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Seattle Seahawks | 23 |
Arizona Cardinals | 20 |
Seattle’s defense and special teams are the difference-makers, allowing them to edge out Arizona in a tightly contested NFC West battle.