Liverpool vs Southampton Lineups: Full Rotation, Predicted XI, and Carabao Cup Preview from Anfield

The Carabao Cup third-round clash between Liverpool and Southampton promises to deliver a fascinating evening under the Anfield lights. With Liverpool boss Arne Slot confirming a completely rotated side, and Southampton looking to seize the opportunity against a youthful Reds squad, both sets of fans are eager to see how the teams will line up. This Liverpool vs Southampton live encounter carries importance for both clubs, albeit for different reasons—Liverpool aiming for squad depth management and Southampton hoping for a statement result.

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Liverpool vs Southampton Lineups: Full Rotation, Predicted XI, and Carabao Cup Preview from Anfield
Liverpool vs Southampton

Liverpool team news vs Southampton

Arne Slot has already confirmed that Liverpool will make wholesale changes for this tie, with up to eleven rotations from the side that secured victory in the Merseyside derby. Big names such as Mohamed Salah, Virgil van Dijk, Ryan Gravenberch, Dominik Szoboszlai, and Ibrahima Konaté are set to be rested.

Instead, the spotlight falls on fringe players and academy talents. Wataru Endō and Curtis Jones are expected to control midfield, while Trey Nyoni and Rio Ngumoha may be handed rare starts. At the back, Joe Gomez and Giovanni Leoni will likely partner in central defense, supported by Jeremie Frimpong and Andy Robertson in full-back roles.

Liverpool vs Southampton predicted lineup

Based on reports, the Reds are expected to set up in a 4-2-3-1 formation, though a switch to 4-3-3 remains possible depending on game dynamics.

Predicted Liverpool XI:

Position Player
Goalkeeper Giorgi Mamardashvili
Right-back Jeremie Frimpong
Centre-back Giovanni Leoni
Centre-back Joe Gomez
Left-back Andy Robertson
Midfield Wataru Endō
Midfield Curtis Jones
Attacking Mid Trey Nyoni
Right Wing Federico Chiesa
Left Wing Rio Ngumoha
Striker Alexander Isak

This Liverpool starting XI vs Southampton underlines the manager’s trust in youth and new signings, while still blending in some experience through Robertson and Gomez.

Southampton lineup vs Liverpool

Southampton boss Will Still has not revealed his exact plans, but with the Championship campaign proving challenging, he may rotate to balance energy across competitions. However, given Liverpool’s rotated side, Southampton could sense an opportunity and field several first-team regulars.

The Saints are expected to focus on defensive organization and quick counterattacks to exploit Liverpool’s less experienced players. Key figures such as their captain and attacking threats may feature from the start, with younger squad members making appearances later in the game.

Liverpool vs Southampton Carabao Cup preview

This tie carries significance for both clubs. For Liverpool, it is a chance to test squad depth, give opportunities to emerging players, and manage a packed fixture calendar. For Southampton, it is a chance to upset Premier League opposition, gain confidence, and progress in a competition that could lift morale.

Match details:

  • Competition: Carabao Cup, Third Round

  • Date: Tuesday, 23 September 2025

  • Kick-off Time: 8:00 PM BST

  • Venue: Anfield, Liverpool

  • Broadcast: Live coverage on ITV and Sky Sports in the UK, with international audiences able to follow via various streaming platforms.

What to Expect in Liverpool vs Southampton live action

Liverpool will likely dominate possession, relying on their midfield structure to dictate play, while Southampton will aim to frustrate the hosts and strike on the break. Fans can expect a high-tempo contest, with both managers viewing the tie as a test of tactical flexibility.

If Liverpool’s youthful lineup can handle the pressure and maintain composure, the Reds should progress. However, Southampton’s determination and experience in tricky fixtures could make this a closely contested Carabao Cup encounter.

The Liverpool vs Southampton live fixture offers an intriguing blend of youth, experience, and competitive spirit. With Arne Slot fielding a fully rotated side and Will Still eyeing a cup upset, the Anfield crowd will witness a tactical battle shaped by energy, squad rotation, and ambition. For Liverpool, it is about giving opportunities without sacrificing results; for Southampton, it is about proving they can punch above their weight on a big stage.