NFL 2025 Week 6 Inactives Update: Kyler Murray Ruled Out for Cardinals

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The NFL 2025 Week 6 schedule brings notable player updates, particularly concerning the Arizona Cardinals and quarterback Kyler Murray. Murray has been ruled out for the upcoming game against the Indianapolis Colts due to a foot injury.

Kyler Murray Ruled Out

Kyler Murray was unable to participate in practice for two consecutive days this week, raising concerns about his availability. Although he made a limited return on Friday, a report indicated on Sunday morning that he would miss the game. The Cardinals officially confirmed his absence 90 minutes before kick-off.

Cardinals’ Quarterback Situation

With Murray sidelined, Jacoby Brissett will take the starting quarterback role for the Cardinals. He will be supported by Kedon Slovis, who was brought up from the practice squad earlier this week.

Inactive Players List

Here is the list of inactive players for both the Cardinals and the Colts:

Cardinals:
- QB Kyler Murray
- CB Elijah Jones
- DL Darius Robinson
- OL Demontray Jacobs
- OL Josh Fryar
- WR Xavier Weaver
- DL Bilal Nichols
Colts:
- RB Tyler Goodson
- CB Kenny Moore
- TE Will Mallory
- WR Adonai Mitchell
- QB Anthony Richardson
- T Luke Tenuta
- DE JT Tuimoloau

Other Major Inactives Across NFL Week 6

This week also features significant player inactives in other matchups:

Rams at Ravens

Rams: WR Tutu Atwell, LB Omar Speights, G Beaux Limmer, T Rob Havenstein, TE Colby Parkinson, DE Deshaun Johnson
Ravens: QB Lamar Jackson, LB Roquan Smith, CB Chidobe Awuzie, FB Pat Ricard, T Carson Vinson, WR Tez Walker, DT Aeneas Peebles

Cowboys at Panthers

Cowboys: WR CeeDee Lamb, OL Tyler Booker, WR KaVontae Turpin, LB Jack Sanborn, DL Mazi Smith, OL Ajani Cornelius
Panthers: TE Ja’Tavion Sanders, CB Akayleb Evans, RB Chuba Hubbard, S Trevian Thomas, T Taylor Moton, DT Jaden Crumedy, DT Tershawn Wharton

Seahawks at Jaguars

Seahawks: QB Jalen Milroe, S Julian Love, CB Devon Witherspoon, CB Riq Woolen, LB Derick Hall, OL Josh Jones, TE Nick Kallerup
Jaguars: S Kahlef Hailassie, RB Cody Schrader, LB Yasir Abdullah, OL Robert Hainsey, DT Khalen Saunders

Chargers at Dolphins

Chargers: WR Quentin Johnston, WR Derius Davis (knee), FB/DL Scott Matlock, OL Jamaree Salyer, T Joe Alt, OL Trey Pipkins, CB Nikko Reed
Dolphins: QB Quinn Ewers, RB Jaylen Wright, CB Storm Duck, DT Zeek Biggers, LB Tyrel Dodson, WR Cedrick Wilson Jr., DB Elijah Campbell

Patriots at Saints

Patriots: QB Tommy Devito, S Jaylinn Hawkins, LB Anfernee Jennings, DT Eric Gregory, G Caedan Wallace, DE Keion White
Saints: S Ugo Amadi, CB Rejzohn Wright, OL Torricelli Simpkins, OL Xavier Truss, DT Khristian Boyd, CB Isaac Yiadom

Browns at Steelers

Browns: CB Jarrick Bernard-Converse, RB Raheim Sanders, DT Mike Hall Jr., T Thayer Munford, G Zak Zinter, T Cornelius Lucas
Steelers: WR Calvin Austin, S Chuck Clark, DL DeMarvin Leal, DL Logan Lee, OL Andrus Peat

This Week 6 matchup and updates reinforce the unpredictability of the NFL season, particularly in key quarterback positions. Fans will want to stay updated as game time approaches.