NFL Week 6: Expert Predictions and Top Bets for 49ers vs Buccaneers Showdown Today
The San Francisco 49ers are set to face the Tampa Bay Buccaneers in an exciting Week 6 matchup of the NFL season. The game will take place at Raymond James Stadium in Tampa, Florida, on Sunday, October 12, 2025, with kickoff scheduled for 4:25 p.m. ET.
49ers Offense vs. Buccaneers Defense
As the game approaches, predictions indicate that the 49ers’ offense will continue its strong performance against the Buccaneers. Despite injuries to key players, including quarterback Brock Purdy, the 49ers are known for their versatile offensive strategy. Mac Jones has stepped in admirably, leading the team to three victories in recent weeks.
Key Matchup Insights
- 49ers team total projected at Over 22.5 (-120)
- 49ers are 5th in success rate per play
- Buccaneers rank 31st in opponent success rate per dropback
- Recent performance shows the Buccaneers allowed an average passer rating of 105.0
In their previous game, Jones threw for 342 yards and two touchdowns, fueling optimism for a strong offensive showing against a struggling Tampa Bay secondary. The Buccaneers have faced challenges with injuries in their defensive backfield, including their top corners, which may expose them to big plays from the 49ers.
Injury Reports and Player Performances
The 49ers are hopeful for the return of some injured players, including wide receiver Juan Jennings. On the other hand, the Buccaneers will be without key players like Chris Godwin and Bucky Irving, factors that may impact their offensive capabilities.
Game Predictions
- Predicted Moneyline: 49ers +108, Buccaneers -127
- Point Spread: 49ers +3.5
- Over/Under Total: 47 points
The 49ers have struggled with red-zone efficiency, currently sitting at 28th in touchdown rate inside the opponent’s 20-yard line. However, the Buccaneers’ defense has given up a staggering 93 points in their last three games, accentuating the opportunity for San Francisco to exploit their weaknesses.
Viewing Information
Fans looking to catch this exciting game can tune into CBS for live coverage. Keep an eye on weather conditions as kickoff approaches, as they can significantly influence game dynamics and betting strategies.
For those interested in betting, expert trends indicate a favorable record for 49ers head coach Kyle Shanahan as a road underdog. With a blend of strong offensive potential and a leaky Buccaneers defense, this game promises to deliver plenty of intrigue and opportunities for both teams.
