Essential insights on melatonin supplements and their impact on heart health risks

New research suggests that long-term use of melatonin supplements may be associated with an increased risk of heart failure. This finding raises concerns for many individuals who use melatonin as a sleep aid.

Research Overview on Melatonin and Heart Health

The study analyzed electronic medical records from over 130,000 adults, focusing on those with chronic insomnia. Participants who used melatonin supplements for over a year demonstrated a 90% higher risk of heart failure over a five-year span compared to a control group that did not use melatonin.

Key Findings

• Melatonin users were over three times more likely to be hospitalized for heart failure.
• Participants using melatonin were about twice as likely to die from any cause.
• The average age of participants was around 55, with 61.4% being women.

Despite these alarming statistics, experts caution against concluding that melatonin is definitively harmful. Many limitations in the study prevent it from establishing a direct cause-and-effect relationship.

Presentation of Findings

This research will be presented at the American Heart Association’s Scientific Sessions 2025, scheduled for November 7-10. Lead researcher Dr. Ekenedilichukwu Nnadi emphasized that more studies are needed to adequately assess melatonin’s safety for heart health, despite its common perception as a natural sleep aid.

Understanding Melatonin

Melatonin is a hormone naturally produced by the pineal gland in response to darkness. It aids in regulating sleep cycles. Supplements can be derived from animal sources or synthesized chemically. In the U.S., melatonin is sold as a dietary supplement, which means it does not undergo the same rigorous safety evaluations as prescription medications.

• Chronic insomnia affects approximately 10% of the global population.
• Symptoms include taking longer than 30 minutes to fall asleep or sleep disruptions three times a week for over three months.

Health Implications of Insomnia

Chronic insomnia can lead to cognitive issues and impair day-to-day functioning. Sleep disorders may also increase the risk of serious cardiovascular events like heart attacks and strokes. This relationship raises questions about the effects of melatonin on heart health.

Limitations and Future Research

Experts note significant limitations in the research. The varied regulations across countries regarding melatonin prescriptions may confound results. Additionally, missing data about participants’ insomnia severity and mental health status limits conclusions regarding the true safety of melatonin supplements.

Current guidelines suggest low-dose, short-term use of melatonin is safe for many adults. However, individuals should consult healthcare professionals before beginning supplementation.

Recommendations for Better Sleep

To improve sleep hygiene, consider the following strategies:

• Limit light exposure and screen time before bed.
• Keep your sleeping environment dark, quiet, and cool.
• Consult a doctor to identify the underlying causes of sleep difficulties.

If opting for melatonin supplements, ensure you choose pharmaceutical-grade products that meet safety verification standards. Always discuss chronic use with a medical professional to avoid potential health risks.